Anti-Mouse Tlr1 (C-term) antibody produced in rabbit

产品说明

一般描述

Higher animals establish host defense by orchestrating innate and adaptive immunity. This is mediated by professional antigen presenting cells, i.e. dendritic cells (DCs). DCs can incorporate pathogens, produce a variety of cytokines, maturate, and present pathogen-derived peptides to T cells, thereby inducing T cell activation and differentiation. These responses are triggered by microbial recognition through type I transmembrane proteins, Toll-like receptors (TLRs) on DCs. TLRs consist of ten members and each TLR is involved in recognizing a variety of microorganism-derived molecular structures. TLR ligands include cell wall components, proteins, nucleic acids, and synthetic chemical compounds, all of which can activate DCs as immune adjuvants. Each TLR can activate DCs in a similar, but distinct manner. For example, TLRs can be divided into subgroups according to their type I interferon (IFN) inducing ability. TLR2 cannot induce IFN-alpha or IFN-beta, but TLR4 can lead to IFN-beta production. Meanwhile, TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. Recent evidences suggest that cytoplamic adapters for TLRs are especially crucial for this functional heterogeneity. This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of mouse TLR1.
The TLR1 gene is mapped to human chromosome 4p14. Tlr1 is widely expressed in several leukocytes and cells of myeloid lineage including monocytes, macrophages, and dendritic cells.

免疫原

TLR1 (Q9EPQ1, 769-805)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of mouse TLR1.

生化/生理作用

The members of the TLR (toll-like receptor) family play important role in host-pathogen interaction by identifying specific molecular patterns in various microorganisms during early innate immune response. The immune and inflammatory responses against microbial infection or tissue injury is controlled by Tlrs by initiating signal cascades and in turn, promoting the secretion of cytokines and chemokines. Tlr1 might be involved in the regulation of mucosal immune response in gut, by forming a heterodimer with Tlr2. Apart from immune cells, TLRs are also expressed on tumor cells and stromal cells. The functional role of Tlr1 is not well understood, therefore, further elucidation is required for clarity over its underlying mechanism.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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