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ATP Citrate Lyase Active human

品牌
Sigma-Aldrich
货号
SRP0288
规格纯度
recombinant, expressed in baculovirus, ≥90% (SDS-PAGE)
参考价格
9013.4 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
ATP Citrate Lyase Active human
ACLY
ATP-citrate synthase
ATPCL
CLATP
产品介绍:

产品说明

一般描述

Human ATP citrate lyase (ACLY) (GenBank Accession No. NM_001096), full length, with N-terminal GST tag, MW = 147 kDa, expressed in baculovirus expression system.

应用

Active human ATP citrate lyase is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Active human ATP citrate lyase has been used in a study to ascertain the nature of the catalytic phosphorylation that initiates the ACL reaction, and to identity the active site residues involved. Active human ATP citrate lyase has also been used in a study to analyze tumor metabolism to reveal mitochondrial glucose oxidation in genetically diverse human glioblastomas.

生化/生理作用

ATP citrate lyase is an enzyme involved in fatty acid synthesis that generates cytosolic acetyl-CoA and oxaloacetate from citrate and CoA. ATP citrate lyase is often upregulated in cancer.

单位定义

One unit is defined as the amount of enzyme required to convert 1 pmol of ADP to ATP/min at 37℃.

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70℃. Note: Enzyme is very sensitive to freeze/thaw cycles.

基本信息

NACRESNA.54

产品性质

重组expressed in baculovirus
测定≥90% (SDS-PAGE)
形式aqueous solution
specific activity≥1.2 pmol/min-μg
分子量 147 kDa
NCBI登记号NM_001096
运输dry ice
储存温度−70℃
Gene Informationmouse ... ACLY(47)

Sigma-Aldrich

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