AZD-7762 hydrochloride

产品名称：

1246094-78-9
AZD-7762 hydrochloride
5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride
AZD 7762 hydrochloride

产品介绍：

产品说明

应用

AZD-7762 hydrochloride has been used:

as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development

包装

5, 25 mg in glass bottle

生化/生理作用

AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.

基本信息

经验(实验)分子式	C₁₇H₁₉FN₄O₂S · HCl
分子量	398.88
MDL编号	MFCD12546135
PubChem化学物质编号	329825353
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to light brown
溶解性	DMSO: 15 mg/mL, clear
储存温度	−20℃
SMILES string	Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3
InChI	1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1
InChI key	WFZBLOIXZRZEDG-YDALLXLXSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H318
预防措施声明	P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
危险分类	Acute Tox. 4 Oral - Eye Dam. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable