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BPTF (2796-2907) GST tag human

品牌
Sigma-Aldrich
货号
SRP6579
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
参考价格
3563.77 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
BPTF (2796-2907) GST tag human
Bromodomain PHD Finger Transcription Factor
产品介绍:

产品说明

一般描述

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BPTF is the largest component of the NURF chromatin remodeling complex. It includes adjacent PHD and bromodomains which recognize trimethylation of H3K4 or acetylation of lysines in histone 4, respectively. BPTF is an essential regulator of gene expression in early mouse embryos, and its knock-out is embryonic lethal. Duplication of the BPTF gene has been suggested to increase proliferation of cultured cancer cells, and aberrant BPTF copy numbers were found in 42% of the “NCI-60” panel of 60 human cancer cell lines. This protein product contains the bromodomain of BPTF.

外形

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.

产品性质

生物来源human
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式liquid
分子量 40.1 kDa (2796-2907 aa + NT GST Tag)
包装pkg of 100 μg
pkg of 20 μg
UniProt登记号Q12830
运输dry ice
储存温度−70℃
Gene Informationhuman ... BPTF(2186)

安全信息

象形图GHS07
警示用语:Warning
危险声明H317 - H319 - H412
预防措施声明P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313
危险分类Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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