LRE1

产品名称：

1252362-53-0
LRE1
6-Chloro-N4-cyclopropyl-N4-(2-thienylmethyl)-2,4-pyrimidinediamine
RU-0204277

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

LRE1 is a selective allosteric inhibitor of soluble adenylyl cyclase (sAC), a ubiquitously expressed, essential component of cAMP-signaling. In contrast to G-protein-regulated transmembrane adenylyl cyclase, soluble adenylyl cyclase is directly activated by calcium and carbonate, and is dispersed throughout the cell cytoplasm. LRE1 was found to bind to the bicarbonate activator binding site. It inhibited cAMP accumulation in 4-4 cells with an IC50 of 11 μM, similar to that of KH7 and without its cellular toxicity.

基本信息

经验(实验)分子式	C₁₂H₁₃ClN₄S
分子量	280.78
MDL编号	MFCD23148480
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃
SMILES string	ClC1=CC(N(C2CC2)CC3=CC=CS3)=NC(N)=N1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3