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ppTG21 trifluoroacetate salt

品牌
Sigma-Aldrich
货号
SML3052
包装型号
规格纯度
≥95% (HPLC)
参考价格
1055.93 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
ppTG21 trifluoroacetate salt
GLFHALLHLLHSLWHLLLHA-OH TFA salt
Gly-Leu-Phe-His-Ala-Leu-Leu-His-Leu-Leu-His-Ser-Leu-Trp-His-Leu-Leu-Leu-His-Ala TFA salt
产品介绍:

产品说明

生化/生理作用

ppTG21 is an endosomolytic agent (pI 7.7, charge +1.3 @ pH 7.4) that facilitates cell type-specific gene editing by enabling endosome escape of Cas9 ribonucleoprotein (RNP) complex following its uptake via receptor-mediated endocytosis. Following liver-specific asialoglycoprotein receptor (ASGPr)-mediated delivery of ASGPr ligand (ASGPrL)-harboring & SV40 nuclear localization sequence (NLS)-bearing S. pyogenes Cas9 (Cas9-2lig-1NLS) RNP with EMX1-targeting sgRNA, target gene editing occurs only upon coincubation of the RNP in the presence of 30 molar equiv of ppTG21 (ave 4.8% indels in HepG2 cells vs. 0.2% indels without ppTG21).

基本信息

经验(实验)分子式C115H173N31O22 · xC2HF3O2
分子量2341.80 (free base basis)

产品性质

质量水平100
测定≥95% (HPLC)
形式film or powder
颜色 white to beige
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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