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Angiogenesis Inhibitor-CAS 186611-44-9-Calbiochem

品牌
Sigma-Aldrich
CAS
186611-44-9
货号
175580
规格纯度
The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
2165.23 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
186611-44-9
Angiogenesis Inhibitor-CAS 186611-44-9-Calbiochem
( Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
(Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
产品介绍:

产品说明

一般描述

A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC50: 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity
Reversible: no
Product competes with ATP.
Primary Target
hEGF-R tyrosine kinase activity

警告

Toxicity: Carcinogenic / Teratogenic (D)

其他说明

Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem.18, 243.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C12H9N3O
分子量211.22

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性DMSO: 5 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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