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Anti-DMP-1 (CT) Antibody, clone 8G10.3

品牌
Sigma-Aldrich
货号
MABD19
规格纯度
clone 8G10.3, from mouse
参考价格
5854.74 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-DMP-1 (CT) Antibody, clone 8G10.3
Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, AG1
产品介绍:

产品说明

一般描述

Dentin matrix protein 1, also known as DMP-1, is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP-1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.

特异性

This antibody detects the C-Terminus of DMP-1.

免疫原

57 kDa fragments isolated from rat bone
Epitope: C-terminus

应用

This Anti-DMP-1 (C-terminus) Antibody, clone 8G10.3 is validated for use in IH, DB for the detection of DMP-1 (C-terminus).
Research Sub Category
Osteobiology
Research Category
Stem Cell Research
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in rat mandibular sections. (Baba, O., et al. (2004). Matrix Biology. 23:371–379.)

Dot Blot Analysis: A representative lot was used by an independent laboratory in DB. (Baba, O., et al. (2004). Matrix Biology. 23:371–379.)

质量

Evaluated by Immunohistochemistry in human tooth sections.

Immunohistochemistry Analysis: 1:50-1:250 dilution of this antibody detected DMP-1 in human tooth sections.

目标描述

53 kDa calculated

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human tooth sections

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆8G10.3, monoclonal
species reactivityhuman
species reactivity (predicted by homology)mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
technique(s)dot blot: suitable
immunohistochemistry: suitable
同位素/亚型IgG1κ
NCBI登记号NP_987089
UniProt登记号P98193
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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