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位置:首页 > 品牌 > Sigma-Aldrich > Guanosine 3',5'-cyclic Monophosphorothioate, β-Phenyl-1,N2-etheno-8-bromo-, Rp-Isomer, Sodium Salt-CAS 172806-20-1-Calbiochem

Guanosine 3',5'-cyclic Monophosphorothioate, β-Phenyl-1,N2-etheno-8-bromo-, Rp-Isomer, Sodium Salt-CAS 172806-20-1-Calbiochem

品牌
Sigma-Aldrich
CAS
172806-20-1
货号
370679
规格纯度
A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM).
参考价格
3124.36 *本价格含增值税费
促销
服务
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数量
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产品名称:
172806-20-1
Guanosine 3',5'-cyclic Monophosphorothioate, β-Phenyl-1,N2-etheno-8-bromo-, Rp-Isomer, Sodium Salt-CAS 172806-20-1-Calbiochem
Rp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI
产品介绍:

产品说明

一般描述

A metabolically-stable, competitive inhibitor of protein kinase G type Iα and Iβ (Ki = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC50 = 25 µM). Also reported to block the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µmol = 2.81 mg.
A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µM) and the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.

包装

1 μmol in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target Ki: 30 nM against PKG1α & 1β
Product does not compete with ATP.
Reversible: no
Primary Target
PKG1α & 1β

警告

Toxicity: Standard Handling (A)

其他说明

Wei, J.Y., et al. 1996. Biochemistry35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C18H14BrN5O6PS · Na
分子量562.27

产品性质

质量水平100
测定≥98% (HPLC)
形式lyophilized
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
溶解性water: 5 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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