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sPLA2-IIA Inhibitor I-Calbiochem

品牌
Sigma-Aldrich
货号
525145
规格纯度
The sPLA2-IIA Inhibitor I controls the biological activity of sPLA2-IIA. This small molecule/inhibitor is primarily used for Cell Signaling applications.
参考价格
2340.22 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
sPLA2-IIA Inhibitor I-Calbiochem
c(2NapA)LS(2NapA)R, TFA
产品介绍:

产品说明

一般描述

A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA2-IIA (human type IIA secreted phospholipase A2; IC50 = 12.8 μM). Shown to effectively block sPLA2-IIA-induced PGE2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μM. Does not have any significant effect on the activities of porcine sPLA2-IB, Naja naja sPLA2-IB, or Crotalus durissus sPLA2-IIA even at 10 μM concentration.
A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of human type IIA secreted phospholipase A2 (sPLA2-IIA) (IC50 = 12.8 µM). Reported to effectively block sPLA2-IIA-induced PGE2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 µM. Does not have any significant effect on the activities of porcine sPLA2-IB, Naja naja sPLA2-IB, or Crotalus durissus sPLA2-IIA at 10 µM.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
sPLA2-IIA (human type IIA secreted phospholipase A2
Product does not compete with ATP.
Reversible: no
Target IC50: 12.8 µM against sPLA2-IIA (human type IIA secreted phospholipase A2
Cell permeable: no

警告

Toxicity: Standard Handling (A)

序列

cyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA

其他说明

Church, W.B., et al. 2001. J. Biol. Chem.276, 33156.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C41H50N8O6 · xC2HF3O2
分子量750.89 (free base basis)

产品性质

质量水平100
测定≥95% (HPLC)
形式lyophilized solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性DMSO: 5 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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