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Anti-Human IgE-Peroxidase antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200755
规格纯度
clone GE-1, purified from hybridoma cell culture
参考价格
6067.58 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Human IgE-Peroxidase antibody, Mouse monoclonal
Anti-Immunoglubulin E
产品介绍:

产品说明

一般描述

Monoclonal Anti-Human IgE (mouse IgG2b isotype) is derived from the GE-1 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgE myeloma protein. IgE (Immunoglobulin E) is the least abundant immunoglobulin isotype. IgE is produced by plasma cells and is highly functional in the lung, skin, and mucous membranes. Normal levels of IgE in serum are less than 1 μmL.

特异性

Monoclonal Anti-Human IgE specifically recognizes Human IgE. The antibody shows no cross-reactivity with human IgG1, IgG2, IgG3, IgG4, IgA, and IgM.

免疫原

Purified human IgE

应用

Anti-Human IgE-Peroxidase antibody has been used in enzyme linked immunosorbent assay (ELISA).

生化/生理作用

IgE plays a critical role in allergic reactions and host protection from parasites. During an allergic reaction such as atopic eczema, extrinsic asthma or hay fever, fungal and parasitic infection, atopic disease, or primary immunodeficiency the serum IgE levels can be induced up to 5-fold. IgE specifically and reversibly binds to the membrane receptor Fc-epsilon receptors (FcεR) type I on the surface of basophils, eosinophils, and mast cells. This binding activates the release of histamine, leukotrienes, and other mediators responsible for hypersensitivity. The recognition and isolation of allergen-specific IgE can lead to progress in understanding of pathophysiologic mechanisms underlying IgE-associated allergic disorders.

外形

Supplied as a lyophilized powder.

其他说明

This product is for R&D use only, not for drug, household, or other uses.

基本信息

NACRESNA.46

产品性质

质量水平200
生物来源mouse
偶联物peroxidase conjugate
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆GE-1, monoclonal
形式lyophilized powder
species reactivityhuman
technique(s)ELISA: 1:20,000-1:30,000 using 5 μg/mL Human IgE myeloma for coating
同位素/亚型IgG2b
运输dry ice
储存温度−20℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H317
预防措施声明P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
危险分类Skin Sens. 1
储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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