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Anti-Gαx/z antibody produced in rabbit

品牌
Sigma-Aldrich
货号
G5165
规格纯度
whole antiserum
参考价格
3455.19 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Gαx/z antibody produced in rabbit
产品介绍:

产品说明

一般描述

G-proteins are membrane associated heterotrimeric proteins that are comprised of α-, β-, and γ-subunits. These proteins play a key role in signal transduction pathways that regulate cell′s response to several hormones, neuromodulators and ligands. The αz subunit is myristoylated near the N-terminus.

免疫原

synthetic peptide corresponding to the C-terminal region of Gαx/z.

应用

Anti-Gαx/z antibody produced in rabbit is suitable for western blot analysis at a working dilution of 1:100-1:200 using plasma membrane fractions.

生化/生理作用

The gene GNAZ (guanine nucleotide binding protein (G protein), αz polypeptide) encodes an α subunit of guanine nucleotide binding proteins. The α-subunit contains a guanine-binding domain that is in its inactive state when it is occupied by GDP. Upon activation, GDP is replaced with GTP, causing the dissociation of the α-subunit from the βγ-subunit complex. This enables the Gα-GTP complex to bind to and regulate specific signaling pathways. GTP is then hydrolyzed, allowing for re-association of the α-subunit with the βγ-subunit complex. When coupled to phospholipase C, the α subunits may have a role in pertussis toxin-insensitive pathways.

基本信息

MDL编号MFCD01092353
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式whole antiserum
antibody product typeprimary antibodies
克隆polyclonal
包含0.1% sodium azide
species reactivitymammals
technique(s)western blot: 1:100-1:200 using plasma membrane fractions
运输dry ice
储存温度−20℃
Gene Informationhuman ... GNAZ(2781)
mouse ... Gnaz(14687)
rat ... Gnaz(25740)

Sigma-Aldrich

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