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位置:首页 > 品牌 > Sigma-Aldrich > D-erythro-Sphingosine, N,N-Dimethyl--CAS 119567-63-4-Calbiochem

D-erythro-Sphingosine, N,N-Dimethyl--CAS 119567-63-4-Calbiochem

品牌
Sigma-Aldrich
CAS
119567-63-4
货号
310500
规格纯度
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 μM) and stimulates Src kinase activity.
参考价格
2165.23 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
119567-63-4
D-erythro-Sphingosine, N,N-Dimethyl--CAS 119567-63-4-Calbiochem
DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
产品介绍:

产品说明

一般描述

A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Target IC50: 12 µM against PKC
Reversible: yes
Primary Target
PKC

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

其他说明

Cuvillier, O., et al. 1996. Nature381, 800.
Ohta, H., et al. 1995. Cancer Res.55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et al. 1991. Biochemistry30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C20H41NO2
分子量327.55

产品性质

质量水平100
测定≥98% (TLC)
形式oil (Clear)
waxy solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
溶解性DMSO: 5 mg/mL
ethanol: soluble
methanol: soluble
运输ambient
储存温度−20℃
InChI1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
InChI keyYRXOQXUDKDCXME-YIVRLKKSSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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