产品说明
一般描述
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Target IC50: ~ 50 nM inhibiting the processing of the p-Prl signal peptide
Reversible: no
Cell permeable: no
Primary Target
Processing of the p-Prl signal peptide
警告
Toxicity: Standard Handling (A)
序列
Z-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
分析说明
single spot by TLC
其他说明
Weihofen, A., et al. 2002. Science296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C43H64N6O9 |
分子量 | 809.00 |
产品性质
质量水平 | 100 |
形式 | lyophilized solid |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze |
颜色 | off-white |
溶解性 | DMSO: 1 mg/mL |
运输 | ambient |
储存温度 | −20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich