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(Z-LL)2 Ketone-Calbiochem

品牌
Sigma-Aldrich
货号
421050
规格纯度
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases.
参考价格
1954.93 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
(Z-LL)2 Ketone-Calbiochem
1,3-Di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
产品介绍:

产品说明

一般描述

A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Target IC50: ~ 50 nM inhibiting the processing of the p-Prl signal peptide
Reversible: no
Cell permeable: no
Primary Target
Processing of the p-Prl signal peptide

警告

Toxicity: Standard Handling (A)

序列

Z-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z

分析说明

single spot by TLC

其他说明

Weihofen, A., et al. 2002. Science296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C43H64N6O9
分子量809.00

产品性质

质量水平100
形式lyophilized solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 off-white
溶解性DMSO: 1 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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