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Granzyme B human

品牌
Sigma-Aldrich
货号
SRE0021
规格纯度
recombinant, expressed in insect cells, ≥90% (SDS-PAGE)
参考价格
6098.33 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Granzyme B human
GranzymeB
Granzyme-2
Lymphocyte protease
T-cell serine protease 1-3E
Cytotoxic T-lymphocyte proteinase 2
SECT
产品介绍:

产品说明

一般描述

Granzyme B (GzmB) is a serine protease which is stored in granules of activated cytotoxic T cells and NK cells. GZMB codes for granzyme B.

生化/生理作用

Granzyme B is considered as the marker of activated CTLs (cytotoxic T-cells), which mediates target-cell apoptosis. It induces apoptosis in caspase-dependent and caspase-independent manner. After contact with target cells, granzyme B is directionally exocytosed, and then enters the target cell with assistance from perforin. Granzyme B specifically cleaves after Asp residues, and particularly processes and activates various pro-caspases. This induces apoptosis in the target cell.

单位定义

One unit is defined as the amount of enzyme that hydrolyzes 1 pmol/min of IETD-AFC per min at 37℃ in 50 mM HEPES, pH 7.5 containing 10 mM CaCl2.

外形

Lyophilized powder, containing HEPES buffer (original solution at pH 7.5)

产品性质

质量水平200
生物来源human
重组expressed in insect cells
测定≥90% (SDS-PAGE)
形式lyophilized powder
效能>0.004 units/mg
specific activity≥40 units/μg
包装pkg of 5 μg
UniProt登记号P10144
运输wet ice
储存温度−20℃
Gene Informationhuman ... GZMB(3002)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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