BD 1063 dihydrochloride

产品名称：

206996-13-6
BD 1063 dihydrochloride
1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride
BD1063 dihydrochloride

产品介绍：

产品说明

应用

BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:

to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells
in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)
to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells

包装

5, 25 mg in glass bottle

生化/生理作用

BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.

其他说明

air sensitive

基本信息

经验(实验)分子式	C₁₃H₁₈Cl₂N₂ · 2HCl
分子量	346.12
MDL编号	MFCD00792740
PubChem化学物质编号	329825284
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	H₂O: >15 mg/mL
储存温度	room temp
SMILES string	Cl.Cl.CN1CCN(CC1)CCc2ccc(Cl)c(Cl)c2
InChI	1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H
InChI key	NXFDBTLQOARIMH-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H319
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable