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CD40-TRAF6 signaling inhibitor

品牌
Sigma-Aldrich
CAS
433249-94-6
货号
SML1160
规格纯度
≥98% (HPLC)
参考价格
1117.23 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
433249-94-6
CD40-TRAF6 signaling inhibitor
Compound 6877002
3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
产品介绍:

产品说明

应用

CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB).

包装

5, 25 mg in glass bottle

生化/生理作用

CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.
CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.

基本信息

经验(实验)分子式C17H17NO
分子量251.32
PubChem化学物质编号329825690
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C
InChI1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+
InChI keyWIFPLULEUNBSTE-GZTJUZNOSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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