BIO-0919278 racemate

产品名称：

1040706-31-7
BIO-0919278 racemate
Compound 702697 racemate
BIO-0702697 racemate
BIO0919278 racemate
N-(1H-Benzo[d]imidazol-2-yl)-2-(1-oxoisoindolin-2-yl)propenamide
Compound 919278 racemate
BIO0702697 racemate
N-1H-Benzimidazol-2-yl-1,3-dihydro-a-methyl-1-oxo-2H-isoindole-2-acetamide

产品介绍：

产品说明

生化/生理作用

BIO-0919278 is a highly selective cyclin-dependent kinase CDK12 inhibitor (K_d = 5.6 μM) with little or no potency against CDK1-7, CDK9, CDK14, CDK16-18 or 344 other kinases (<35% inhibition at 1 μM). BIO-0919278 reduces CDK12-mediated Pol II CTD Ser2 phosphorylation (by 57% at 1 μM; U-2 OS cells) without affecting CDK12-independent Pol II CTD Ser5 phosphorylation, and selectively targets noncanonical NF-κB activation (4-hr 20 ng/mLTWEAK-induced p52 nuclear translocation/NIK mRNA production IC50 = 167/320 nM; U-2 OS cells) without affecting canonical NF-κB activation (TNF-α-stimulated p65 (RelA) nuclear translocation IC50 >30 μM).

基本信息

经验(实验)分子式	C₁₈H₁₆N₄O₂
分子量	320.35

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable