(1R, 2R)-N-myristoylamino-4′-nitro-phenylpropandiol-1, 3

产品名称：

35922-06-6
D-NMAPPD
[R-(R*,R*)]-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide
(1R,2R)-B13
B13
(1R, 2R)-N-myristoylamino-4′-nitro-phenylpropandiol-1, 3
N-[(1R,2R)-2-Hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]tetradecanamide

产品介绍：

产品说明

生化/生理作用

D-NMAPPD (B13), a myristoyl-CoA analog, is a cell penetrant inhibitor of N-myristoyltransferases that suppressed FRS2α (fibroblast growth factor receptor substrate 2) myristoylation. D-NMAPPD inhibits wild-type FGFRs and drug-resistant mutants (FGFRsDRM) oncogenic signaling in cancer cells. D-NMAPPD potently inhibits growth of xenograft tumors in mice. D-NMAPPD is a potent inhibitor of ceramidase that elevates endogenous ceramide levels and suppress growth of cancer cells.

基本信息

经验(实验)分子式	C₂₃H₃₈N₂O₅
分子量	422.56
MDL编号	MFCD08062172

产品性质

测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -28 to -34, c = 0.1 in chloroform-d
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable