Enzastaurin

产品名称：

170364-57-5
Enzastaurin
D04014
LY-317615
3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
LY317615

产品介绍：

产品说明

应用

Enzastaurin has been used in splicing analysis to study its effects on splicing of a mutated exon.

包装

5, 25 mg in glass bottle

生化/生理作用

Enzastaurin is a potent and PKCβ preferring inhibitor. Also, Enzastaurin inhibits AKT and GSK3β. Enzastaurin acts as anti-angiogenic and antineoplastic agent.
It is an orally administered drug. It can induce apoptosis, inhibit angiogenesis and proliferation of cells. Enzastaurin can be used for the treatment of haematological cancers.

特点和优势

This compound is featured on the GSK-3, PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₃₂H₂₉N₅O₂
分子量	515.60
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	, light orange to dark orange-red
溶解性	DMSO: 10 mg/mL, clear (warmed)
储存温度	−20℃
InChI	1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
InChI key	AXRCEOKUDYDWLF-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H413
预防措施声明	P273 - P301 + P312 + P330
危险分类	Acute Tox. 4 Oral - Aquatic Chronic 4
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable