ETaKG

产品名称：

ETaKG
5-Ethyl 1-(3-(trifluoromethyl)benzyl) 2-oxopentanedioate
2-Oxo-pentanedioic acid 5-ethyl ester 1-(3-trifluoromethyl-benzyl) ester

产品介绍：

产品说明

生化/生理作用

ETaKG is a cell-permeable, aqueous stable, bioavailable, non-toxic α-ketoglutarate/2-oxoglutarate (α-KG/2-OG) diester derivative that readily undergoes hydrolysis by cytosolic esterases to α-KG. The monoester analog, TaKG is also membrane permeant. ETaKG elevates intracellular [α-KG] by ~15-fold in a prologned fashion, destabilizes HIF-1α/2α and reactivates prolyl hydroxylases (PHDs) in hypoxic HCT116, A431 and RPE cells at 2 mM. Further, shown to selectively trigger PHD-dependent cell death in hypoxic cells and decreases cellular [ATP] and glucose uptake. ETaKG has shown to reduce glucose metabolism, elevate [α-KG] levels and suppress A375 xenograft tumor growth (750 mg/kg of mice, p.o., q.d., 14 days). Also, induces mTORC1 lysosomal translocation and stimulates mTORC1 activity in the absence of glutaminolysis in U2OS cells.

基本信息

经验(实验)分子式	C₁₅H₁₅F₃O₅
分子量	332.27
PubChem化学物质编号	329826049
NACRES	NA.77

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	oil
颜色	colorless to light yellow
储存温度	2-8℃
SMILES string	O=C(C(CCC(OCC)=O)=O)OCC1=CC=CC(C(F)(F)F)=C1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable