Febrifugine dihydrochloride

产品名称：

32434-42-7
Febrifugine dihydrochloride
3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.
Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).

基本信息

经验(实验)分子式	C₁₆H₁₉N₃O₃ · 2HCl
分子量	374.26
PubChem化学物质编号	329825583
NACRES	NA.77

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
旋光性	[α]/D 10 to 15°, c = 1 in H₂O
储存条件	desiccated
颜色	off-white to gray-brown
溶解性	H₂O: 15 mg/mL, clear
储存温度	−20℃
SMILES string	O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
InChI	1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
InChI key	SNTOTCUGCWLHEZ-KKJWGQAZSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable