Phenanthriplatin

产品名称：

Phenanthriplatin
PhenPt
(SP-4-3)-Diamminechlorido(phenanthridine)platinum(II) nitrate
cis-[Pt(NH3)2(phenanthridine)Cl]NO3

产品介绍：

产品说明

生化/生理作用

Phenanthriplatin is a cationic monofunctional DNA-binding platinum (II) complex with significantly greater anticancer activity (IC₅₀ in μM = 0.035/Ntera2, 0.22/A549, 0.30/HeLa, 0.59/U2OS, 0.74/PC3, 0.94/MCF7, 2.02/HT29; 72 h, MTT assay) than cisplatin, oxaliplatin, and pyriplatin. Enhanced cellular uptake due to its hydrophobic phenanthridine ligand as well as more rapid DNA covalent-binding activity both contribute to its superior anticancer efficacy. Phenanthriplatin binds more effectively to 5′-deoxyguanosine monophosphate than to N-acetyl methionine, whereas pyriplatin reacts equally to both.

基本信息

经验(实验)分子式	C₁₃H₁₅ClN₄O₃Pt
分子量	505.81

产品性质

质量水平	100
测定	>97% (NMR)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	Cl[Pt](N)([N+]1=C2C=CC=CC2=C3C=CC=CC3=C1)N.[O-][N+]([O-])=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3