NMDAR-TRPM4 blocker C8 dihydrochloride

产品名称：

2243506-33-2
NMDAR-TRPM4 blocker C8 dihydrochloride
Compound 8 dihydrochloride
C8 dihydrochloride
N1-[(3-Bromophenyl)methyl]-N1-ethyl-1,2-ethanediamine dihydrochloride

产品介绍：

产品说明

生化/生理作用

Compound 8 (C8) is a small molecule that directly targets TRPM4 TwinF domain and blocks its interaction with GluN2A/GluN2B (NR2A/NR2B) I4 domain. C8 prevents NMDAR/TRPM4 interaction-dependent excitotoxicity (death protection EC50 = 2.1 μM 24 h post 10-min exposure of primary murine hippocampal neurons to 20 μM NMDA) without affecting, and even enhancing, NMDAR-mediated essential functions. C8 protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell (RGC) loss in mice in vivo (40 mg/kg i.p. at -16h, -3h before, 0h, 3h, 24h after MCAO or 20 nmol NMDA/2.0 μL by intravitreal injection).

基本信息

经验(实验)分子式	C₁₁H₁₇BrN₂·2HCl
分子量	330.09
MDL编号	MFCD31668685

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder or solid
储存条件	desiccated
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear
储存温度	−20℃
SMILES string	NCCN(CC)CC1=CC=CC(Br)=C1.Cl.Cl

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable