O4I3

产品名称：

88965-00-8
O4I3
6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine
2-(4-Methylphenyl)-6-methylimidazo[1,2-a]pyridine
OCT4-inducing compound 3

产品介绍：

产品说明

生化/生理作用

O4I3 is a highly potent and KDM5A (JARID1A) subtype-selective H3K4 demethylase KDM5 inhibitor (KDM5A IC₅₀ = 0.15 nM vs KDM5B/C/D IC₅₀ = 125.2/9.76/4.7 nM, KDM4 IC₅₀ = 249 nM, LSD1 IC₅₀ >100 μM) that effectively induces OCT4 expresson and improves OSKM-induced pluripotent stem cell (iPSC) reprogramming efficiency of human primary fibroblasts (50 nM) by preventing KDM5A from interfering with H3K4Me3 enrichment at the OCT4 promoter. O4I3 promotes hPSC homeostasis and represses cellular differentiation, increasing hPSCs viability up to 4-fold at a low 10 nM concentration when compared with Rock inhibitor Y-27632 treatment at 10 μM.

基本信息

经验(实验)分子式	C₁₅H₁₄N₂
分子量	222.29
MDL编号	MFCD00444739

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	CC1=CC=C(C2=CN3C=C(C=CC3=N2)C)C=C1

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3