产品说明
应用
SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice.
包装
5, 25 mg in glass bottle
生化/生理作用
SKF-83959 is an atypical agonist of D1 dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D1 receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D1 receptors coupled to adenylyl cyclase.
D1 dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.
基本信息
| 经验(实验)分子式 | C18H20NClO2 · HBr |
| 分子量 | 398.72 |
| MDL编号 | MFCD03792727 |
| PubChem化学物质编号 | 24278699 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 颜色 | white |
| 溶解性 | DMSO: >20 mg/mL H2O: insoluble |
| SMILES string | Br[H].CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c3cccc(C)c3 |
| InChI | 1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H |
| InChI key | FHYWNBUFNGHNCP-UHFFFAOYSA-N |
| Gene Information | human ... DRD1(1812) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
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