TFLLR-NH2 trifluoroacetate salt

产品名称：

TFLLR-NH2 trifluoroacetate salt
L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt
Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt

产品介绍：

产品说明

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

应用

TFLLR-NH₂ trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

包装

5, 25 mg in glass bottle

生化/生理作用

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

制备说明

TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

基本信息

经验(实验)分子式	C₃₁H₅₃N₉O₆ · xC₂HF₃O₂
分子量	647.81 (free base basis)
MDL编号	MFCD05663482
PubChem化学物质编号	329826874
NACRES	NA.77

产品性质

质量水平	100
测定	>98% (HPLC)
形式	lyophilized powder
颜色	white to tan
溶解性	H₂O: >2 mg/mL
储存温度	−20℃
SMILES string	OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
InChI	1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1
InChI key	QVNWOGSDGQDGHP-MKVNCOEFSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable