产品说明
一般描述
BGP-15 is a hydroxylamine derivative, which has cytoprotective and neuroprotective properties. It reduces phospho- c-Jun N-terminal kinase (pJNK) and p38 stress signalling. BGP-15 also stimulates non-specific serine/threonine protein kinase (AKT) and insulin-like growth factor 1 receptor (IGFR1) protective signalling. BGP-15 functions as an insulin sensitizer in an olanzapine-induced metabolic disorder. It protects cells against cell death and enhances the expression of heat shock protein (HSP). BGP-15 might be used to treat heart failure (HF) and atrial fibrillation (AF).
应用
BGP-15 has been used to study its influence on proteasomal degradation of missense dystrophins.
包装
5, 25 mg in glass bottle
生化/生理作用
BGP-15 is PARP inhibitor, HSP72 activator.
基本信息
| 经验(实验)分子式 | C14H22N4O2· 2HCl |
| 分子量 | 351.27 |
| MDL编号 | MFCD21603901 |
| PubChem化学物质编号 | 329773244 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 溶解性 | deionized water: 28 mg/mL |
| 储存温度 | −20℃ |
| SMILES string | Cl.Cl.N\C(=N/OCC(O)CN1CCCCC1)c2cccnc2 |
| InChI | 1S/C14H22N4O2.2ClH/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18;;/h4-6,9,13,19H,1-3,7-8,10-11H2,(H2,15,17);2*1H |
| InChI key | ISGGVCWFTPTHIX-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 |
| 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 |
| 危险分类 | Acute Tox. 3 Oral |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
