Calhex 231 hydrochloride

产品名称：

652973-93-8
Calhex 231 hydrochloride
4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride

产品介绍：

产品说明

应用

Calhex 231 hydrochloride has been used:

as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats
to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)
to test its effect on acoustic response bias in zebrafish
in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )

包装

5, 25 mg in glass bottle

生化/生理作用

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC₅₀ of 0.36 μM.

基本信息

经验(实验)分子式	C₂₅H₂₇ClN₂O · HCl
分子量	443.41
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 15 mg/mL, clear
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable