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Monoclonal Anti-MAGE-1 antibody produced in mouse

Monoclonal Anti-MAGE-1 小鼠抗

品牌
Sigma-Aldrich
货号
M6320
规格纯度
~2 mg/mL, clone MA454, purified immunoglobulin, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-MAGE-1 antibody produced in mouse
Anti-Melanoma-associatiated antigen 1
Monoclonal Anti-MAGE-1 小鼠抗
产品介绍:

产品说明

一般描述

Melanoma-associatiated antigen 1 (MAGE-1) is part of the CG (cancer-germline) group of genes and is a tumor-specific antigen. MAGE-1 is a member of the MAGE-A family. MAGE-1 gene is localized on human chromosome Xq28. Monoclonal Anti-MAGE-1 (mouse IgG1 isotype) is derived from the hybridoma MA454 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from mice immunized with human recombinant MAGE-1.

特异性

The antibody does not recognize MAGE-2 and MAGE-3.

免疫原

recombinant human MAGE-1.

应用

Monoclonal Anti-MAGE-1 antibody produced in mouse has been used in:

  • ELISA
  • immunoblotting
  • immunohistochemistry

生化/生理作用

The melanoma antigen genes (MAGE) might play a key role in neural development and apoptosis. Expression of melanoma-associated antigen 1 (MAGE-1) in neoplastic cells depends on the binding of the transcription factor Ets to non-methylated cis regulatory sequences, located in its promoter. MAGE-1 expression is mediatedby the B and B′ domains of MAGE-A1 gene. Expression of MAGE-1A was induced in non MAGE-A1 expressing tumor cells once treated with demethylating reagent, 5-aza-2-(5DC). Melanoma-associatiated antigen 1 (MAGE-1) has been shown to be expressed in different types of cancers.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD03096998
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆MA454, monoclonal
形式buffered aqueous solution
分子量antigen ~46 kDa
species reactivityhuman
包装antibody small pack of 25 μL
浓度~2 mg/mL
technique(s)immunohistochemistry: suitable
indirect ELISA: suitable
western blot: 5-10 μg/mL using total cell extract of SKML37 cells
同位素/亚型IgG1
UniProt登记号P43355
运输dry ice
储存温度−20℃
Gene Informationhuman ... MAGEA1(4100)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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