InSolution NF-κB Activation Inhibitor-Calbiochem

产品说明

一般描述

A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC₅₀ = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC₅₀ = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.

包装

1 mg in Plastic Bag(s)
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Cell permeable: yes
Primary Target
NF-κB transcriptional activation
Reversible: no
Target IC₅₀: 11 nM against NF-κB transcriptional activation in Jurkat cells; 7 nM against LPS-induced TNF-α production in murine splenocytes

警告

Toxicity: Toxic (F)

外形

A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481406) in DMSO.

重悬

Following initial use, aliquot and refrigerate (4°C).

其他说明

Tobe, M., et al. 2003. Bioorg. Med. Chem.11, 383.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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