N-(4-Butyl-2-methylphenyl)-N′-hydroxymethanimidamide

产品名称：

339068-25-6
HET0016
N-(4-Butyl-2-methylphenyl)-N′-hydroxymethanimidamide
N-Hydroxy-N′-(4-n-butyl-2-methylphenyl)formamidine
HET 0016
N-(4-Butyl-2-methylphenyl)-N′-hydroxyformamidine
HET-0016
N′-(4-Butyl-2-methylphenyl)-N-hydroxymethanimidamide

产品介绍：

产品说明

生化/生理作用

HET0016 is a potent and selective inhibitor against cytochrome P450 (CYP450) ω-hydroxylases (human CYP4A11/4A22/4F2/4F3, rat CYP4A1/4A2/4A3/4A8)-mediated 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis (IC50 = 8.9/35 nM using human/rat renal microsomes), exhibiting much reduced potency against epoxyeicosatrienoic acids (EETs) biosynthesis (IC50 = 2.8 μM/rat microsome) or the enzyme activities of CYP2C9/2D6/3A4 and COX (IC50 = 3.3/83.9/71 μM and 2.3 μM). HET0016 is widely employed both in cultures (1-10 μM) and in aminals in vivo (1-10 mg/kg via i.v., i.m., i.p. or s.c.) for probing 20-HETE-dependent physiological and pathological processes.

基本信息

经验(实验)分子式	C₁₂H₁₈N₂O
分子量	206.28

产品性质

测定	≥95% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	CCCCC1=CC=C(C(C)=C1)/N=C/NO

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable