5-Amino-1-methylquinolinium iodide

产品名称：

42464-96-0
5-Amino-1-methylquinolinium iodide
5-Amino-1-methylquinolinium, iodide (1:1)
5-Amino-1MQ iodide
5-Amino-1-MQ iodide

产品介绍：

产品说明

生化/生理作用

5-Amino-1-methylquinolinium (5-amino-1MQ) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC₅₀ = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC₅₀ = 30μM) and adipocytes 1-methylnicotinamide level (EC₅₀ = 2.3 μM) without affecting related methyltransferases & enzymes in the NAD+ salvage pathway. 5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid. sc.), and intraperitoneal HeyA8 ovarian cancer metastasis (20 mg/kg/d ip.) with no adverse effects to the animals (up to 60 mg/kg/d). Note:1.89 mg iodide salt contains 1 mg eq of 5-amino-1MQ.

基本信息

经验(实验)分子式	C₁₀H₁₁N₂·I
分子量	286.11

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	faint red to dark brown
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	C[N+]1=CC=CC2=C(C=CC=C12)N.[I-]

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable