Ispinesib

产品名称：

336113-53-2
Ispinesib
N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide
SB715992
(R)-N-(3-Aminopropyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide
SB 715992
CK0238273
SB-715992

产品介绍：

产品说明

生化/生理作用

Ispinesib (SB-715992) is a potent and highly selective kinesin spindle protein (KSP, KIF11, EG5) allosteric inhibtor that specifically inhibits microtubule (MT)-stimulated ATPase activity of KSP (K_i = 1.7 nM; 5 μM MT, 500 μM ATP, 0.75 nM human KSP), but not ubiquitous kinesin heavy chain KHC, neuronal kinesin KIF1A, or mitotic kinesins CENP-E, RabK6, MCAK, MKLP1. Ispinesib exhibits anti-cancer efficacy in cultures (GI₅₀ = 45 nM/BT-474 & 19 nM/MDA-MB-468) and in cancer xenograft models in vivo (8 or 10 mg/kg q4d×3 ip. mice with MCF-7, HCC-1954, KPL4, BT-474 xenografts).

基本信息

经验(实验)分子式	C₃₀H₃₃ClN₄O₂
分子量	517.06
MDL编号	MFCD22628831

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D +315 to +375°, c = 0.5 in chloroform-d
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

象形图
警示用语：	Danger
危险声明	H300 + H330 - H341
预防措施声明	P202 - P260 - P264 - P270 - P271 - P304 + P340 + P310
危险分类	Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Muta. 2
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3