Anti-Activin Receptor IIA antibody produced in goat

产品说明

一般描述

Activin is a disulfide-linked dimeric protein released by granulosa cells in the ovary and sertoli cells in the testis. It has several functions which include bone remodeling, neural cell differentiation, reproductive physiology, hematopoiesis and mesoderm induction. Activin will not bind directly to Type I activin receptors rather it will associate with the type II receptor-activin complex and start signal transduction. Activin Receptor IIA belongs to Ser/Thr protein kinase family, is highly conserved and can bind to inhibin, BMP-2, and BMP-7 with lower affinities. Goat anti-activin receptor IIA antibody reacts specifically with recombinant human activin receptor IIA. The antibody exhibits approximately 2% cross-reactivity with recombinant human activin receptor I and recombinant human activin receptor IIB.
The antibody has the ability to block receptor-ligand interaction. In ELISA assays, it will block 50% of the binding of recombinant human activin A to recombinant human activin receptor IIA/Fc chimera.

免疫原

recombinant human activin receptor IIA expressed in Sf 21 insect cells.

应用

Goat anti-Activin receptor IIB (ActRIIB) was used to detect activin receptor IIB in muscle fibroblasts by western blot. The antibody recognized activin receptor IIB at roughly 50kDa.
Anti-Activin Receptor IIA antibody can be used in in western blotting (working concentration:-0.1-0.2 μg/mL) and indirect ELISA (working concentration -0.5-1.0 μg/mL) for detecting human activin receptor IIA.
Goat Activin Receptor IIA antibody is suitable for immunohistochemistry assays at 15μg/ml.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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