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Pixantrone dimaleate

品牌
Sigma-Aldrich
CAS
144675-97-8
货号
SML2577
规格纯度
≥98% (HPLC)
参考价格
928.71 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
144675-97-8
Pixantrone dimaleate
6,9-Bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate
Pixantrone maleate
BBR 2778
BBR2778
2-Azaanthracene-9,10-dione dimaleate
BBR-2778
产品介绍:

产品说明

生化/生理作用

Pixantrone (BBR 2778) is an aza-anthracenedione with enhanced antitumor activity due to its DNA-intercalating and topoisomerase II-poisoning activity. Pixantrone shows no signs of acute or delayed cardiotoxicity seen with anthracyclines mitoxantrone and doxorubicin (DOX), while exhibiting comparable in vivo efficacy against solid tumors in mice. Tests conducted on human myocardial strips ex vivo shows that not only pixantrone does not form superoxide anion and hydrogen peroxide (O2•− and H2O2) seen with DOX due to redox activation, pixantrone and its metabolites, especially N-dealkylated, show competitive inhibition against DOX reduction. While mitoxantrone does not form O2•− and H2O2 on its own, it synergizes with DOX to form more O2•− and H2O2, whose formation and subsequent production of the long-lived metabolite doxorubicinol contribute to DOX cardiotoxicity.

基本信息

经验(实验)分子式C17H19N5O2 · C8H8O8
分子量557.51
MDL编号MFCD00920108

产品性质

测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 purple to dark blue
溶解性H2O: 2 mg/mL, clear
储存温度2-8℃
InChI1S/C17H19N5O2.2C4H4O4/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24;2*5-3(6)1-2-4(7)8/h1-3,6,9,21-22H,4-5,7-8,18-19H2;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1+
InChI keySVAGFBGXEWPNJC-LVEZLNDCSA-N

安全信息

象形图GHS08
警示用语:Warning
危险声明H341 - H361d
预防措施声明P201 - P308 + P313
危险分类Muta. 2 - Repr. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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